The North America Oligonucleotide Synthesis Market is expected to reach US$ $ 1,541.03 Mn in 2027 from US$ 609.90 Mn in 2018. The market is estimated to grow with a CAGR of 11.2% from 2019-2027.

North America Oligonucleotide Synthesis Market – Strategic Overview

The growth of the North America Oligonucleotide Synthesis Market is being propelled by several key factors, including increased investments in pharmaceutical and biotechnology sectors, government funding, and a rising number of market players with a strong focus on this domain. These drivers are expected to significantly enhance market expansion across the region during the forecast period.

North America Oligonucleotide Synthesis Market, short single-stranded DNA sequences, serve as essential tools in numerous biological and medical applications. Their ability to bind sequence-specifically makes them valuable in identifying specific DNA targets. Synthetic oligonucleotides are extensively used in fields such as disease diagnostics, biotechnology research, therapeutics, forensics, and drug discovery. Notably, they play a crucial role in diagnosing genetic disorders. For example, labeled oligonucleotide probes can detect single base pair mutations in the human genome, such as the A-to-T transversion in the β-globin gene responsible for sickle cell anemia. These probes allow precise identification of mutated alleles under stringent hybridization conditions.

Additionally, oligonucleotides contribute to greener and more efficient chemical synthesis processes. When assembled into longer DNA fragments that encode synthetic genes, they can be used to program yeast or bacterial cells to produce targeted enzymes, enabling sustainable biomanufacturing practices.

In the realm of therapeutics, oligonucleotides offer promising potential to modulate, silence, or correct malfunctioning genes. Ionis Pharmaceuticals, for instance, has been at the forefront of developing antisense oligonucleotide (ASO) therapies aimed at addressing genetic disorders. This capability further reinforces the market’s potential.

NORTH AMERICA OLIGONUCLEOTIDE SYNTHESIS MARKET SEGMENTATION

North America Oligonucleotide Synthesis Market By Product

• Synthesized Oligonucleotides
  • Primers
  • Probes
  • Large-Scale Synthesis
  • Others
• Reagents
  • Equipment

North America Oligonucleotide Synthesis Market By Application

• Research
• Diagnostics
• Therapeutics

North America Oligonucleotide Synthesis Market By End User

• Academic Research Institutes
• Pharmaceutical & Biotechnology Companies
• Diagnostic Laboratories
• Other End Users

North America Oligonucleotide Synthesis Market By Geography

• North America
  • US
  • Canada
  • Mexico

North America Oligonucleotide Synthesis Market Company Profiles

• Thermo Fisher Scientific Inc.
• GenScript
• Molecular Assemblies
• Twist Biosciences
• Evonetix
• DNA Script
• Nuclera Nucleics
• Camena Bioscience
• Synthomics
• Ansa Biotechnologies

Recent clinical trials, such as those conducted in Canada, are also expected to positively impact the oligonucleotide synthesis market. For instance, a Phase 3 trial initiated in January 2019 enrolled adults with Huntington’s disease in the United States and Canada to evaluate the investigational therapy RG6042 (initially known as IONIS-HTTRx). This antisense oligonucleotide treatment, developed by Ionis Pharmaceuticals and later acquired by Roche, is designed to target and degrade different forms of the mutant huntingtin protein (mHTT), the primary cause of Huntington’s disease. This multi-site trial across five Canadian provinces underscores the growing clinical interest in oligonucleotide-based therapies.

Within North America, the United States is projected to be the leading market. This dominance is attributed to increasing investments and dedicated funding directed towards manufacturing companies, as well as academic and research institutions, for the development of gene synthesis-based end products such as precision medicine and other therapeutics. Considering these factors, the growth of the North America Oligonucleotide Synthesis Market in the US is expected to contribute the largest share within the North American region during the forecast period.

North America Oligonucleotide Synthesis Market Strategic Insights

Strategic insights for the North America Oligonucleotide Synthesis market offer a data-driven analysis of the industry landscape, encompassing current trends, key players, and regional specificities. These insights provide actionable recommendations, empowering stakeholders to differentiate themselves by identifying underserved market segments or developing unique value propositions. By leveraging data analytics, these insights enable industry participants, including investors and manufacturers, to anticipate market shifts. Adopting a future-oriented perspective is crucial, allowing stakeholders to proactively position themselves for long-term success in this dynamic region. Ultimately, effective strategic insights equip readers with the knowledge necessary to make informed decisions that drive profitability and achieve their business objectives within the North America Oligonucleotide Synthesis Market.

Other Reports:

North America Contrast Media Injectors Market: https://penzu.com/p/33699068fa603bd7 

North America Digital Transformation Market: https://postyourarticle.com/north-america-digital-transformation-market-opportunities-trends-and-forecasts-2025/ 

North America Visual Analytics Market: https://business-news-insights.blogspot.com/2025/04/north-america-visual-analytics-market.html 

North America Data Center Construction Market: https://sites.google.com/view/northamericadatacenterconstruc/home 

About Us:

Business Market Insights is a market research platform that provides subscription service for industry and company reports. Our research team has extensive professional expertise in domains such as Electronics & Semiconductor; Aerospace & Defense; Automotive & Transportation; Energy & Power; Healthcare; Manufacturing & Construction; Food & Beverages; Chemicals & Materials; and Technology, Media, & Telecommunications.

Author’s Bio:

Suryakant Gadekar

Senior Market Research Expert at Business Market Insights